时 间：2023年12月6日16:00
地 点：实验教学主楼822会议室
主 持 人：高 灿 教授
报 告 人：刘 妍 博士
题 目：Peptide TAT-T407 protects against neuron apoptosis and cognitive deficits after cerebral ischemia by dissociating TRPV1 from CDK5
主要内容：
Cerebral ischemia/reperfusion (I/R) injury, characterized by progressive motor and cognitive dysfunction, has long been considered to be driven by neuronal apoptosis. However, the precise mechanisms underlying neuronal apoptosis in ischemic stroke remain poorly understood. Here, we found that binding of TRPV1 and CDK5 could lead to severe brain damage during cerebral I/R injury. Accordingly, we synthesized a short interference peptide TAT-T407 which can interrupt the binding of TRPV1 and CDK5. Application with TAT-T407 peptide not only resulted in a dramatic reduction in cerebral infarct volume, which was consistent with a parallel enhancement in neurological function, but also alleviated neuronal apoptosis in the ischemic areas following cerebral I/R injury. In conclusion, inhibiting TRPV1/CDK5 interaction by administration of TAT-T407 peptides protects against neuron apoptosis and cognitive impairment, which may provide a promising novel therapeutic approach for the clinical treatment of ischemic stroke.
